Wnt signaling in human and mouse breast cancer: Focusing on Wnt ligands, receptors and antagonists

The Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy

Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...

Structurally Related Receptors and Antagonists Compete for Secreted Wnt Ligands

tian and Moon, 1993) outside the organizer (Figure 1). Julia A. Yang-Snyder,* and Jeffrey R. Miller* Both specialists and nonspecialists examining these *Howard Hughes Medical Institute patterns of gene expression can appreciate Spemann’s and Department of Pharmacology image of interlocking fragments, and appreciate why †Molecular and Cellular Biology Program dissecting the workings of the gast...

Dysregulation of Wnt Signaling in Breast Cancer

Wnt signaling and cancer.

The regulation of cell growth and survival can be subverted by a variety of genetic defects that alter transcriptional programs normally responsible for controlling cell number. High throughput analysis of these gene expression patterns should ultimately lead to the identification of minimal expression profiles that will serve as common denominators in assigning a cancer to a given category. In...

EphB/EphrinB receptors and Wnt signaling in colorectal cancer.

Eph receptors and their ephrin ligands mediate cell repulsion during embryonic development. In the intestinal epithelium, EphB receptors are Wnt signaling target genes that control cell compartmentalization along the crypt axis. Recent findings have shown that this family of receptors are key players during colorectal cancer progression. Here, we review the current knowledge of the EphB/ephrinB...